Koolertron 45?11cm Sound music Activated Car Stickers Equalizer Glow Red Light by Koolertron Buy new: $29.99 2 used & new from $22.99 (Visit the Hot New Releases in Car Audio list for authoritative information on this product?s current rank.)
Very Hot: #10: Koolertron 45?11cm Sound music Activated Car Stickers Equalizer Glow Red Light
mario manningham mario manningham williams syndrome hoya casa de mi padre corned beef and cabbage diners drive ins and dives
ScienceDaily (Oct. 29, 2012) ? The respected national Institute of Medicine estimates that $750 billion is lost each year to wasteful or excessive health care spending. This sum includes excess administrative costs, inflated prices, unnecessary services and fraud -- dollars that add no value to health and well-being.
If those wasteful costs could be corralled without sacrificing health care quality, how might that money be better spent?
In a study published in the current online edition of the American Journal of Preventive Medicine, Frederick J. Zimmerman, professor and chair of the department of health policy and Management at the UCLA Fielding School of Public Health, and colleagues outline some of the myriad ways that $750 billion could benefit Americans.
"If cut from current health care expenditures, these funds could provide businesses and households with a huge windfall, with enough money left over to fund deficit reduction on the order of the most ambitious plans in Washington," Zimmerman said. "The money could also cover needed investments in transportation infrastructure, early childhood education, human capital programs, rural development, job retraining programs and much more. And it could transform America with little to no reduction in the quality of, or access to, health care actually provided."
Zimmerman noted that while different observers would likely have different priorities regarding the alternative uses toward which the wasted expenditures could be directed, all would agree that the alternatives proposed in this study have inherent social value.
"When the fastest-growing part of the economy is also the least efficient, the economy as a whole loses its ability over time to support our current living standards," said Jonathan Fielding, a UCLA professor of health policy and management and director of the Los Angeles County Department of Public Health, who is a co-author of the study. "The U.S. has become irrationally attached to its inefficient health care system. Recognizing the opportunity costs of this attachment is the first step in repairing the system."
In the study, the research group, which also included Dr. Steven Teutsch, chief science officer of the Los Angeles County Department of Public Health, and first author Jeffrey C. McCullough, a graduate student at the UCLA Fielding School, presented one scenario of how that money could be used.
For one, the authors propose that more than $410 billion per year -- or 55 percent of the savings -- could be returned to the private sector for individuals and companies to use as they please; another $202 billion (27percent) could go toward deficit reduction, yielding a greater reduction than the congressional "super committee" sought and failed to achieve. An additional $104 billion (14 percent) could support additional investments in human capital and physical infrastructure.
"For example," Zimmerman said, "the Head Start program could be doubled in size, universal preschool could be provided, average class size could be reduced from 22-25 to 13-17 students. And trained nurses could conduct regular home visits for high-risk pregnancies."
Two percent of the savings, amounting to $18 billion, could promote urban and rural quality of life by improving the built environment surrounding schools, expanding and modernizing public libraries, improving wastewater treatment and providing rural development grants to every small town in the nation. Job-training opportunities would be affordable for nearly 50,000 unemployed persons. And under the research group's scenario, the remaining 2 percent of the savings would be devoted to fully funding an extensive wish list of transportation projects to alleviate road congestion and promote mass transit alternatives.
Freeing up this money would be no easy task, Fielding warned. These excess expenditures will be difficult to reduce because the costs are spread across many groups, and the financial beneficiaries are coordinated, clear-minded and powerful, he said. Overcoming this resistance will require concerted collective action on the part of many economic sectors, governmental agencies and other organizations that are not used to seeing themselves as sharing interests with the others.
But whatever one's values and preferences, said Zimmerman, "eliminating excess medical care costs provides a monumental opportunity to reallocate those resources to strengthen our international competitiveness, enhance our well-being and build a healthier nation."
The result of redirecting some $750 billion per year, he said, could be transformative for Americans, and the potential uses for these funds are panoramic in both scope and possibility.
"This will not be an easy fight," Zimmerman said. "But we believe reconceptualizing our excess health care spending by looking at its opportunity cost to society is an important first step."
Share this story on Facebook, Twitter, and Google:
Other social bookmarking and sharing tools:
Story Source:
The above story is reprinted from materials provided by University of California - Los Angeles. The original article was written by Mark Wheeler.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/Krzw9qgcS_M/121030143218.htm
new york auto show 2012 tulsa easter eggs pineapple upside down cake free ecards flying car masters golf tournament
With Microsoft's latest operating system officially official now, we can certainly expect a massive wave of Windows 8-tailored peripherals to be ready to meet most consumer needs. Naturally, Korean electronics giant LG is expected to be one of many manufacturers leading the way, and thus it's no surprise the outfit has announced its Touch 10 ET83 monitor. According to the Optimus G maker, this 23-inch, touchscreen-enabled IPS panel will be a perfect choice for folks utilizing Windows 8, allowing them to take full advantage of Redmond's hefty implementation of gesture-based controls within the OS. The Touch 10's set to be available in Korea in November (mum's the word on pricing), while availability in other markets around the globe is expected to be sometime shortly thereafter.
Continue reading LG announces 23-inch Touch 10 monitor with Windows 8 optimization
Filed under: Displays, Misc, LG
LG announces 23-inch Touch 10 monitor with Windows 8 optimization originally appeared on Engadget on Wed, 31 Oct 2012 17:31:00 EDT. Please see our terms for use of feeds.
Permalink
Akihabara News | 
LG | Email this | CommentsSource: http://www.engadget.com/2012/10/31/lg-touch-10-et83-monitor-windows-8/
ok go peyton manning super bowl nsx chad ochocinco roman numerals new england patriots madonna
A man uses his mobile phone to photograph a closed and flooded subway station in lower Manhattan, in New York, Tuesday, Oct. 30, 2012. New York City awakened Tuesday to a flooded subway system, shuttered financial markets and hundreds of thousands of people without power a day after a wall of seawater and high winds slammed into the city, destroying buildings and flooding tunnels. (AP Photo/Richard Drew)
A man uses his mobile phone to photograph a closed and flooded subway station in lower Manhattan, in New York, Tuesday, Oct. 30, 2012. New York City awakened Tuesday to a flooded subway system, shuttered financial markets and hundreds of thousands of people without power a day after a wall of seawater and high winds slammed into the city, destroying buildings and flooding tunnels. (AP Photo/Richard Drew)
NEW YORK (AP) ? New York City's fast-paced technology scene, known as Silicon Alley, tried not to lose a step after Hurricane Sandy knocked out power lines, devastated the public transit system and left portions of the city flooded.
On Tuesday, companies from small startups to major players such as Google and Facebook, scrambled to balance employee safety with attempts to conduct business as usual. With laptops, smartphones and a dash of the ingenuity tech companies powered through the adverse conditions? or at least tried to.
Silicon Alley is a booming part of New York City's economy. It is both a location ? many technology startups are housed in the lower part of Manhattan? and a state of mind, since many companies have now sprouted across the East River in Brooklyn and elsewhere.
Like many New Yorkers, scads of technology workers toiled from home or hunkered down with coworkers who still had electricity. That was certainly the case among employees of trendy e-commerce site Fab.com on Tuesday. Fab's headquarters is located in the West Village, which was flooded and without power. At 6 a.m. on Tuesday, the company's 225 or so New York-based employees received an email titled "team together." The message asked whether people with electric power might open their homes to co-workers who were without power. In a few hours, 114 people responded.
By noon, there were 12 people working out of CEO Jason Goldberg's two-bedroom apartment on 42nd Street. Other workers gathered in apartments in Manhattan's midtown Hell's Kitchen neighborhood, in Brooklyn and other parts of the city. Two people, who'd flown in from Germany and India before the storm hit in some unfortunate timing also joined Goldberg after they were evacuated from their hotel rooms.
"No one wants to be sitting around doing nothing," Goldberg said in a telephone interview from his apartment, where his dog barked in the background as more employees arrived. "Everyone wants to keep things going."
Some 20 Fab.com employees planned to host co-workers in their homes overnight on Tuesday.
Google Inc. closed its sprawling New York City offices, located on 9th Avenue between 15th and 16th streets in Manhattan's Chelsea neighborhood. The company, which is headquartered in Mountain View, Calif., has about 2,000 employees in its New York office. Google said the safety of its employees is its focus. The office will be closed until further notice, the company said.
The online search leader bought the 15-story, 2.9-million-square-foot building ?which has more space than the Empire State Building ? in 2010. In addition to housing its own offices, Google leases out much of the space, hosting many data centers. Data centers house other companies' servers, which store the vast amounts of data found on websites.
Google did not say whether the building had power as of Tuesday afternoon.
One data center flooded in Sandy's wake knocked popular New York blogs, including Gawker.com, off the Internet. The gossip and media blog, and other Gawker Media sites, responded by creating alternate websites where readers could get the latest information, whether they wanted to read about Sandy or the Octomom.
"Our New York City data center is still offline thanks to Hurricane Sandy. We are working as quickly as possible to restore the full site, but in the interim you can view updates at http://updates.gawker.com," read a message on Gawker.com on Tuesday afternoon.
Facebook's office on Madison Avenue was officially closed, with most of the 200 or so New York-based employees working from home. Though the office had power, getting to work would have been a daunting task for car-free city dwellers, and New York's subway system was still shut down.
For Quirky.com, whose users collaborate in designing household products and accessories, Superstorm Sandy left a flooded basement and the loss of power. Though they work on the seventh floor, for now, the site's 70 employees are working from home until power is restored, said Jaime Yandolino in an email.
Brooklyn-based MakerBot, a 37/8D printing company, was closed on Tuesday, but workers logged in from home. CEO Bre Pettis said the office had power and Internet access. The office will be open Wednesday.
"We were prepared for the worst and luckily came out with the best," Pettis said in a telephone interview from home, as his baby cried in the background.
Associated Press2012 predictions new years eve ball drop new years eve times square 2012 2012 holidays prosperity japan earthquake bosom buddies
TOKYO (Reuters) - Honda Motor Co cut its full-year net profit forecast by a fifth after sales in China were hit by a popular backlash against Japanese goods, and warned it could be February before business in the world's biggest autos market returns to normal.
The cut, prompted by a slump in sales amid often violent protests in a dispute about ownership of islands in the East China Sea, makes it likely that bigger Japanese rival Nissan Motor , and possibly Toyota Motor , will follow suit when they report quarterly earnings early next week.
"It's likely Toyota and Nissan are going to cut forecasts in the same way. A cut was to be expected because the problems with China weren't factored into forecasts," said Fujio Ando, managing director at Chibagin Asset Management.
Demand for Honda, Toyota and Nissan cars slumped in China in September as tempers flared in the territorial dispute, with South Korea's Hyundai Motor and Germany's BMW
Sales by Honda and its China joint ventures dropped 40.5 percent last month. China is Honda's second-biggest market after the United States, accounting for 17 percent of 2011 sales.
Honda said on Monday that its two biggest China plants would continue to run on one shift, rather than two, until at least the middle of next month, with output then gradually picking up ahead of Chinese New Year in February - a traditional buying season. It cut its full-year China sales forecast by 17 percent to 620,000 vehicles, but said there would be no change to its investment there. Honda plans to invest $880 million to expand capacity at its plants in Guangzhou and Wuhan over the next few years.
"China is the world's biggest auto market and there's no doubt it will continue to grow. We will continue our current (investment) plan," Executive Vice President Tetsuo Iwamura told a results briefing.
Honda, whose models include the Accord, Fit/Jazz, Civic and CR-V, cut its net profit forecast for the year to March to 375 billion yen ($4.7 billion) from 470 billion yen. Last year, Honda reported net profit of 211.5 billion yen. It also cut its forecasts for annual operating profit and revenue, citing uncertain markets in China, Europe and India.
Shares in Honda - which fell 15 percent to near 9-month lows amid the China protests - ended 4.7 percent lower at 2,399 yen, their biggest one-day fall in nearly 5 weeks.
Honda released its quarterly earnings three hours earlier than planned, after accidentally posting the results on its website. It took down the numbers, but was told by the Tokyo Stock Exchange to bring forward the full announcement, a Honda spokeswoman said.
Net profit for July-September rose 36.1 percent to 82.2 billion yen ($1.03 billion), some way below the average estimate of 107.2 billion yen from six analysts polled by Thomson Reuters I/B/E/S. A year ago, Japanese manufacturers were still reeling from the March earthquake and tsunami.
Honda's quarterly profits were also dented by start-up and advertising costs for the new Accord sedan, which went on sale in the United States in September, but the refresh helped Japan's third-biggest automaker increase its share of the U.S. car and light truck market to 8.7 percent in September.
The fallout from the Japan-China dispute could run into the current and fourth quarters, analysts have warned. Takaki Nakanishi, an analyst at Bank of America Merrill Lynch in Tokyo, said the impact could, at best, last 3 months, and up to 6 months in a pessimistic scenario.
CEO Takanobu Ito, 59, an engineer who took charge three years ago, has set a demanding goal to nearly double global car sales to 6 million in four years. Worldwide production jumped 69 percent in April-September to above 2 million vehicles.
The carmaker on Monday trimmed its full-year global sales forecast to 4.12 million vehicles from an earlier estimate of 4.3 million. It said vehicle sales in July-September rose 47 percent to 996,000.
Toyota and Nissan report their quarterly earnings on November 5 and November 6, respectively.
Last week, Hyundai increased its quarterly net profit by 13 percent to $2 billion, but several European automakers felt the squeeze of the region's debt crisis, with Peugeot
($1 = 79.5600 Japanese yen)
(Additional reporting by Sophie Knight; Editing by Ian Geoghegan)
Source: http://news.yahoo.com/honda-slashes-net-profit-forecast-china-backlash-hits-032225216--finance.html
bill o brien portland trailblazers will kopelman casey anthony leann rimes dakota fanning casey anthony video diary
'},"otherParams":{"t_e":1,".intl":"US"},"events":{"fetch":{lv:2,"sp":"1197280665","ps":"LREC,MON","npv":true,"bg":"#FFFFFF","em":escape('{"site-attribute":"_id=\'ee871d82-e078-3ee6-b26a-4c59e0f606cd\' sensitivity=\'0\' rs=\'lmsid:a097000000MqtFvAAJ\' ctype=\'fn_news;News\' ctopid=\'2299500;1063000;1504489;1560500;1859000;1094000;2313500;2319000;2319500;1542500;1076000;2320000;1092000;9174489;1506489;1480989;2332500\' can_suppress_ugc=\'1\' content=\'no_expandable;ajax_cert_expandable;\' ADSSA"}'),"em_orig":escape('{"site-attribute":"_id=\'ee871d82-e078-3ee6-b26a-4c59e0f606cd\' sensitivity=\'0\' rs=\'lmsid:a097000000MqtFvAAJ\' ctype=\'fn_news;News\' ctopid=\'2299500;1063000;1504489;1560500;1859000;1094000;2313500;2319000;2319500;1542500;1076000;2320000;1092000;9174489;1506489;1480989;2332500\' can_suppress_ugc=\'1\' content=\'no_expandable;ajax_cert_expandable;\' ADSSA"}')}}};var _createNodes=function(){var nIds=_conf.nodeIds;for(var i in nIds){var nId=nIds[i];var dId=_conf.destinationMap[nIds[i].replace("yom-","")];n=Y.one("#"+nId);if(n)var center=n.one("center");var node=Y.one("#"+dId);var nodeHTML;if(center && !node){nodeHTML=_conf.nodes[nId];center.insert(nodeHTML);};};};var _prepareNodes=function(){var nIds=_conf.nodeIds;for(var i in nIds){var nId=nIds[i];var dId=_conf.destinationMap[nIds[i].replace("yom-ad-","")];n=Y.one("#"+nId);if(n)var center=n.one("center");var node=Y.one("#"+dId);if(center && node){center.set("innerHTML","");center.insert(node);node.setStyle("display","block");};};};var _darla;var _config=function(){if(YAHOO.ads.darla){_darla = YAHOO.ads.darla;_createNodes();};};var _fetch=function(spaceid,adssa,ps){ if (typeof(ps)!='undefined') _conf.events.fetch.ps = ps;if(typeof spaceid != "undefined") _conf.events.fetch.sp=spaceid;adssa = (typeof adssa != "undefined" && adssa != null) ? escape(adssa.replace(/\"/g, "'")) : "";_conf.events.fetch.em=_conf.events.fetch.em_orig.replace("ADSSA", adssa);if(_darla){_prepareNodes();_darla.setConfig(_conf);_darla.event("fetch");};};Y.on("domready", function(){_config();});;var that={"fetch":_fetch,"getNodes":_conf.nodes,"getConf":_conf};return that;}();/* Backwards compatibility - Assigning the latest instance to the main fetch function */YUI.PhotoAdsDarla.fetch=YUI.PhotoAdsDarla.photoslightboxdarla.fetch; }); Y.later(10, this, function() {YAHOO.namespace('Media.Social').Lightbox = {}; }); Y.later(10, this, function() {Y.Media.Article.init(); }); Y.later(10, this, function() {new Y.Media.AuthorBadge(); }); Y.later(10, this, function() {new Y.Media.Branding(); }); Y.later(10, this, function() {Y.on("load", function () { YUI.namespace("Media.SocialButtons"); var instances = YUI.Media.SocialButtons.instances || [], globalConf = YAHOO.Media.SocialButtons.conf || {}, vplContainers = []; Y.all(".ymsb").each(function (node) { var id = node.get("id"), conf = YAHOO.Media.SocialButtons.configs[id], instance; if (conf) { instance = new Y.SocialButtons({ srcNode: node, config: Y.merge(globalConf, conf.config || {}), contentMetadata: conf.content || {}, tracking: conf.tracking || {} }); vplContainers.push( { selector: "#" + id, callback: function(node) { instance.render(); instance = conf = id = null; } }); if (conf.config && conf.config.dynamic) { instances.push(instance); } } }); Y.Global.Media.ViewportLoader.addContainers(vplContainers); YUI.Media.SocialButtons.instances = instances; }); }); Y.later(10, this, function() {if (!Y.Media) { return; } Y.Media.boba_lightbox_module_targets = Y.Media.boba_lightbox_module_targets || {}; Y.Media.boba_lightbox_module_configs = Y.Media.boba_lightbox_module_configs || {}; Y.Media.boba_lightbox_module_dataset = Y.Media.boba_lightbox_module_dataset || {}; Y.Media.boba_lightbox_module_whitelist = Y.Media.boba_lightbox_module_whitelist || {}; Y.Media.boba_lightbox_module_dataset['72777830cce33774de5b476c7057ae1c'] = []; Y.Media.boba_lightbox_module_configs['72777830cce33774de5b476c7057ae1c'] = {"spaceid":"1197280665","ult_pt":"story-lightbox","darla_id":"","images_total":0,"xhr_url":"\/_xhr\/related-article\/lightbox\/?id=ee871d82-e078-3ee6-b26a-4c59e0f606cd","xhr_count":20,"autoplay_if_first_item_is_video":true}; }); Y.later(10, this, function() {new Y.Media.RelatedArticle({count:"2",start:"1", mod_total:"10", total:"0", content_id:"ee871d82-e078-3ee6-b26a-4c59e0f606cd", spaceid:"1197280665", related_count:"-1" }); }); Y.later(10, this, function() {(function(d){ d.getElementsByTagName('head')[0].appendChild(d.createElement('script')).src='http://d.yimg.com/oq/js/csc_news-en-US-core.js'; })(document); }); Y.later(10, this, function() { if(!("Media" in YAHOO)){YAHOO.Media = {};} if(!("ugcrate" in YAHOO.Media)){YAHOO.Media.ugcrate = {};} if(!("Media" in Y)){Y.namespace("Media");} YAHOO.Media.ugcrate.ratings_4ffa2f9bea8f816af2b949f6275a3abe = new Y.Media.UgcRate({"context_id":"d4e46f51-766b-4b75-8126-49ec8f8fad35","sCrumb":"54KWaS.s5eM","containerId":"yom-sentimentrate-4ffa2f9bea8f816af2b949f6275a3abe","rateDimensions":"d1","appLang":"en-US","sUltSId":"1197280665","sUltProperty":"news-en-US","sUltCampaign":"","sUltPlatform":"ugcwidgets","sUltIntl":"US","sUltLang":"en-US","selfPageUrl":"http:\/\/news.yahoo.com\/twitter-building-windows-8-app-134216705.html?_esi=0","artContentId":"42c7f826-95e9-3885-abdb-39e16dd4bd7d","sUltQstnTxt":"Are you considering the Microsoft Surface over the iPad?","artContentTitle":"Twitter Building a Windows 8 App","artContentDesc":"For anyone who\\'s spent time with Windows 8 or its doppelganger, the ARM chip-friendly Windows RT, this will come as welcome news: Twitter has a native Windows 8 client in the works.","sUltBucketId":"test1","sUltSection":"sentirating","sUltBeaconUrl":"","sUltRecordPageviews":"1","sUltBeaconEnable":"1","serviceUrl":"\/_xhr","publisherContextId":"","propertyId":"2fcd79b5-b3a3-333e-b98e-722536a6698f","configurationId":"435db9ee-c55e-3766-b20d-c8ad3ff889d1","graphId":"","labelLeft":"No way!!","labelRight":"Absolutely!","labelMiddle":"","itemimg":"http:\/\/l.yimg.com\/a\/i\/ww\/met\/yahoo_logo_us_061509.png","selfURI":"","aggregateRatingCount":"4372","aggregateReviewCount":"0","leftBlocksNum":"1996","rightBlocksNum":"2375","leftBlocksPerCent":"46","rightBlocksPerCent":"54","ugcrate_apihost":"api01-us.ugcl.yahoo.com:4080","publisher_id":"news-en-US","yca_cert":"yahoo.ugccloud.app.trusted_proxies","timeout_write":"5000","through_proxy":"false","optionStats":"{\"s1\":1375,\"s2\":132,\"s3\":108,\"s4\":173,\"s5\":208,\"s6\":2375,\"s7\":0,\"s8\":0,\"s9\":0,\"s10\":0}","l10N":"{\"FIRST_TO_READ\":\"You are first to read this. Share your feelings and start a conversation.\",\"SHARE_YOUR_FEELINGS\":\"You too can share your feelings and start a conversation!\",\"HOW_YOUR_FRIENDS_THINK\":\"Share your response with your friends on Facebook\",\"PRE_SHARE_MSG\":\"Your Facebook friends on Yahoo! can see how you responded to this question. To share your response on Facebook, click on the Facebook share option.\",\"START_THE_CONVERSATION\":\"Share\",\"THANKS_FOR_SHARING\":\"Your response has been shared with your friends on Facebook\",\"POLL_HEADER\":\"SOCIAL SENTIMENT\",\"SERVER_ERROR\":\"Oops there seems to be some error, please try again later\",\"LOADING\":\"Loading...\",\"SHARE_AFTER_COMMENT\":\"Your response has been shared on Facebook.\",\"UNDO\":\"Undo\",\"UNIT_PEOPLE\":\"People\",\"NUM_PEOPLE_DISAGREE\":\"disagree with your opinion.\",\"READ_MORE_TEXT\":\"Read what they have to say.\",\"SLIDER_THUMB_WORDING_BEFORE_VOTING\":\"WHAT DO YOU THINK?\",\"SLIDER_THUMB_WORDING_VERB_BEFORE_VOTING\":\"DRAG\",\"SLIDER_THUMB_WORDING_THANKS_VOTING\":\"Thanks for voting\",\"NUM_PEOPLE_ANSWERED\":\" 4,372 people have responded to this question\",\"ONE_PERSON_ANSWERED\":\" 1 person has responded to this question. Your response will be seen by your Facebook friends on Yahoo!\",\"TWO_PEOPLE_ANSWERED\":\" 2 people have responded to this question. Your response will be seen by your Facebook friends on Yahoo!\",\"NUM_PEOPLE_ANSWERED_AND_SHARED\":\" 4,372 people have responded to this question. Your response will be seen by your Facebook friends on Yahoo!\",\"NUM_PEOPLE_RATED__s1\":1375,\"NUM_PEOPLE_RATED__s2\":132,\"NUM_PEOPLE_RATED__s3\":108,\"NUM_PEOPLE_RATED__s4\":173,\"NUM_PEOPLE_RATED__s5\":208,\"NUM_PEOPLE_RATED__s6\":2375,\"NUM_PEOPLE_RATED__s7\":0,\"NUM_PEOPLE_RATED__s8\":0,\"NUM_PEOPLE_RATED__s9\":0,\"NUM_PEOPLE_RATED__s10\":0}","fbconfig":"{\"message\":\"undefined\",\"name\":\"undefined\",\"link\":\"\",\"source\":\"\",\"picture\":\"http:\\\/\\\/l.yimg.com\\\/a\\\/i\\\/ww\\\/news\\\/2011\\\/09\\\/27\\\/yahoo-tc.jpg\",\"description\":\"\",\"captionLeft\":\"undefined\",\"captionRight\":\"undefined\",\"app_id\":\"196660913708276\",\"redirect_uri\":\"\\\/_xhr\\\/ugcratefbredirect\\\/\"}","template_id":"LONG_SLIDER_SOUTH","obj_id":"ratings_4ffa2f9bea8f816af2b949f6275a3abe","opt_count":"6","opt_color1":"","opt_color2":"","template_html":"
Source: http://news.yahoo.com/microsoft-windows-phone-catch-apps-190943695--finance.html
rock salt david letterman march of dimes james randi wargames blake griffin dunk florida primary
ScienceDaily (Oct. 28, 2012) ? Due to the exponential increase in sequencing capacity, efficient tools for data analysis are becoming essential to process the vast amount of biological data. The GEM project, led by Paolo Ribeca from the Centro Nacional de An?lisis Gen?mico (CNAG) and including scientists from this center and the Center for Genomic Regulation (CRG), allowed the development of a tool for the interpretation of genomic data that is several times faster and much more accurate than other tools currently being used.
The study has been published in the journal Nature Methods.
If we use the well-known comparison of the genome with a book, then we can say without fear of being wrong that it is a very complicated book. It is thousands of times bigger than a regular book, with more than 3 billion letters in total, each one being an A, C, G or T, as per the four possible bases of the DNA code. One can see the genome as a sequence of millions of words without breaks between them nor capitalization nor punctuation. Most words occur only once in the genome, but some can be found thousands of times with small variations. And reading this book gets even more complicated when you can only see short sentences with few words, each one randomly extracted from the book.
Last generation sequencing techniques used at the CNAG and the CRG, involve breaking the genome into small pieces (alike to short sentences from the book), sequencing such pieces and trying to find them back in the genome. The next step, mandatory in most biological experiments, would be assigning the sentences to their correct original location. However, this can be an extremely difficult task: sentences might be misspelled (sequencing is not a perfect process, and introduces errors) or slightly different (the genome of the individual being sequenced usually contains small variations if compared to the reference one). In addition, each sequencing experiment produces billions of short sentences.
This is the starting point that led some researchers at the CRG and the CNAG to design a computer program that helps to find sequences in the reference genome, quickly and accurately: such tools, called 'mappers', are essential to interpret data in genomic studies, as they represent the first analysis step for many biological experiments. After 5 years of development the result is the GEM (Genomic Multitool) mapper.
The GEM mapper is several times faster than other reference programs in the field and delivers breathtaking performance, matching into the huge human genome of reference about 40 million sequences per hour on a single CPU core. As it uses algorithms that guarantee that it doesn?t miss matches, GEM is also much more accurate than other comparable programs. In addition, GEM allows the parameters of the search to be tuned to the specific requirements of the biological experiment being performed, offering a versatility that cannot be achieved with most existing tools.
The good performance profile of GEM will help to face a practical problem: the dramatic increase in the amount of sequencing data. As an example, the CNAG started operations in 2010 with a park of 12 second generation sequencers that generated roughly 50 Gbases per day. Thanks to the recent spectacular advances in sequencing technology, today, only 2 and a half years after, the CNAG generates almost 20 times more data with the same number of sequencing machines. However, it would have been impossible to increase the computing resources of the CNAG accordingly (and this is a problem common to biomedical research everywhere in the world). Hence, the development of more efficient analysis tools like GEM is essential to keep up with the increasing rate of production.
The GEM tools are a neat example of excellence research, and a world-class tool, entirely developed in Spain; although the project is lead by an Italian team member, the whole work has been carried out in Barcelona. This accomplishment was made possible by the very early adoption of next-generation sequencing machines at the CRG (in 2008), and the subsequent sustained investment in sequencing technologies by the Catalan and Spanish governments that culminated in the creation of the CNAG.
The research was funded by the Spanish Ministerio de Educaci?n y Ciencia (Consolider program), by the US National Institutes of Health/National Human Genome Research Institute, and by the European Union (READNA and ESGI programs).
Share this story on Facebook, Twitter, and Google:
Other social bookmarking and sharing tools:
Story Source:
The above story is reprinted from materials provided by Centre for Genomic Regulation, via AlphaGalileo.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/L46guf0r71M/121028142215.htm
chipper jones chipper jones dancing with the stars cast mickael pietrus heart transplant the international preppers
This full page VOTE NO ad appeared in the business section of the Star Tribune today (Monday, October 29, 2012). It was signed by 79 Minnesota business leaders who want to keep our state a place that attracts and retains the best and brightest.
Star Tribune Business Section, Monday, October 29, 2012
Full Size PDF
Source: http://project515.org/minnesota-business-non-profit-leaders-voting-no/
macauly culkin joe namath stefon diggs nazi ss andrej pejic naomi watts macaulay culkin
{cptn}","template_name":"ss_thmb_play_ttle","i18n":{"end_of_gallery_header":"End of Gallery","end_of_gallery_next":"View Again"},"metadata":{"pagination":"{firstVisible} - {lastVisible} of {numItems}","ult":{"spaceid":"2145868275","sec":""}}},{"id": "hcm-carousel-1590902135", "dataManager": C.dmgr, "mediator": C.mdtr, "group_name":"hcm-carousel-1590902135", "track_item_selected":1,"tracking":{ "spaceid" : "2145868275", "events" : { "click" : { "any" : { "yui-carousel-prev" : { "node" : "a", "data" : {"sec":"HCMOL on article right rail","slk":"prev","itc":"1" }, "bubbles" : true, "test": function(params){ var carousel = params.obj.getCarousel(); var pages = carousel._pages; // if same page, don't beacon if(("_ult_current_page" in carousel) && carousel._ult_current_page==pages.cur) return false; // keep track of current position within this closure carousel._ult_current_page = pages.cur; return true; } }, "yui-carousel-next" : { "node" : "a", "data" : {"sec":"HCMOL on article right rail","slk":"next","itc":"1" }, "bubbles" : true, "test": function(params){ var carousel = params.obj.getCarousel(); var pages = carousel._pages; // no more pages, don't beacon again // if same page, don't beacon if(("_ult_current_page" in carousel) && carousel._ult_current_page==pages.cur) return false; // keep track of current position within this closure carousel._ult_current_page = pages.cur; return true; } } } } } } })); }); Y.later(10, this, function() {(function() { try{ if (Math.floor(Math.random()*10) == 1) { var loc = window.location, decoded = decodeURI(loc.pathname), encoded = encodeURI(decoded), uri = loc.protocol + "//" + loc.host + encoded + ((loc.search.length > 0) ? loc.search + '&' : '?') + "_cacheable=1", xmlhttp; if (window.XMLHttpRequest) xmlhttp = new XMLHttpRequest(); else xmlhttp = new ActiveXObject("Microsoft.XMLHTTP"); xmlhttp.open("GET",uri,true); xmlhttp.send(); } }catch(e){} })(); }); Y.later(10, this, function() {Y.namespace("Media").ywaSettings = '"projectId": "10001256862979", "documentName": "", "documentGroup": "", "ywaColo" : "vscale3", "spaceId" : "2145868275" ,"customFields" : { "12" : "classic", "13" : "story" }'; Y.Media.YWA.init(Y.namespace("Media").ywaSettings); }); Y.later(10, this, function() {if(document.onclick===YAHOO.Media.PreventDefaultHandler.newClick){document.onclick=YAHOO.Media.PreventDefaultHandler.oldClick;} }); }); });
Source: http://news.yahoo.com/washington-metro-remain-closed-tuesday-morning-205129330.html
the bachelor good morning america red meat bachelor ben jon hamm kim kardashian law school rankings jon hamm
{cptn}","template_name":"ss_thmb_play_ttle","i18n":{"end_of_gallery_header":"End of Gallery","end_of_gallery_next":"View Again"},"metadata":{"pagination":"{firstVisible} - {lastVisible} of {numItems}","ult":{"spaceid":"7665145","sec":""}}},{"id": "hcm-carousel-1902807035", "dataManager": C.dmgr, "mediator": C.mdtr, "group_name":"hcm-carousel-1902807035", "track_item_selected":1,"tracking":{ "spaceid" : "7665145", "events" : { "click" : { "any" : { "yui-carousel-prev" : { "node" : "a", "data" : {"sec":"HCMOL on article right rail","slk":"prev","itc":"1" }, "bubbles" : true, "test": function(params){ var carousel = params.obj.getCarousel(); var pages = carousel._pages; // if same page, don't beacon if(("_ult_current_page" in carousel) && carousel._ult_current_page==pages.cur) return false; // keep track of current position within this closure carousel._ult_current_page = pages.cur; return true; } }, "yui-carousel-next" : { "node" : "a", "data" : {"sec":"HCMOL on article right rail","slk":"next","itc":"1" }, "bubbles" : true, "test": function(params){ var carousel = params.obj.getCarousel(); var pages = carousel._pages; // no more pages, don't beacon again // if same page, don't beacon if(("_ult_current_page" in carousel) && carousel._ult_current_page==pages.cur) return false; // keep track of current position within this closure carousel._ult_current_page = pages.cur; return true; } } } } } } })); }); Y.later(10, this, function() {(function() { try{ if (Math.floor(Math.random()*10) == 1) { var loc = window.location, decoded = decodeURI(loc.pathname), encoded = encodeURI(decoded), uri = loc.protocol + "//" + loc.host + encoded + ((loc.search.length > 0) ? loc.search + '&' : '?') + "_cacheable=1", xmlhttp; if (window.XMLHttpRequest) xmlhttp = new XMLHttpRequest(); else xmlhttp = new ActiveXObject("Microsoft.XMLHTTP"); xmlhttp.open("GET",uri,true); xmlhttp.send(); } }catch(e){} })(); }); Y.later(10, this, function() {Y.namespace("Media").ywaSettings = '"projectId": "10001256862979", "documentName": "", "documentGroup": "", "ywaColo" : "vscale3", "spaceId" : "7665145" ,"customFields" : { "12" : "classic", "13" : "story" }'; Y.Media.YWA.init(Y.namespace("Media").ywaSettings); }); Y.later(10, this, function() {if(document.onclick===YAHOO.Media.PreventDefaultHandler.newClick){document.onclick=YAHOO.Media.PreventDefaultHandler.oldClick;} }); }); });
Source: http://news.yahoo.com/des-moines-register-endorses-romney-president-201704241--politics.html
matt bomer westminster kennel club dog show jeremy lin game winner chocolate covered strawberries shrimp scampi kate upton si cover lobster recipes
In a lot of ways, with Windows 8, Microsoft got the jump on what Apple seems intent on doing with OS X and iOS: a convergence of desktop and mobile computing. But the approaches both companies are taking to changing consumer computing habits are very different, and both strategies have their merits and their pitfalls. So who will come out on top as the world figures out new digital paradigms?Source: http://feedproxy.google.com/~r/Techcrunch/~3/aXuesj5Q-1E/
mark davis marine urination video hostess cadillac ats bain capital marines urinating haley barbour
NASHUA, N.H. (AP) ? President Barack Obama is seeking to win over voters in low-tax New Hampshire by criticizing Mitt Romney for raising taxes and fees when he was governor of neighboring Massachusetts.
Obama says Romney is making "a lot of last-minute promises." But he says the policies the Republican is pushing are the same ones the Democratic campaign contends hurt the middle class in Massachusetts.
The president says Romney even tried to raise fees in Massachusetts on getting a birth certificate, "which would have been expensive for me." It was a veiled reference those who have incorrectly claimed Obama was born outside the United States.
Obama spoke to about 8,500 people at an outdoor rally on an unseasonably warm October day in New England.
Source: http://finance.blogrange.com/finance-news/obama-hits-romney-on-taxes-massachusetts-record/
kurt busch nba dunk contest 2012 act of valor woody guthrie benson henderson 2012 dunk contest edgar vs henderson
With less than two weeks to go before Election Day, support for Jerry Brown's tax hike has plunged below 50 percent in two polls. If it fails, $6 billion in automatic cuts kick in.
California Gov. Jerry Brown makes a point while speaking in support of Proposition 30 at an elementary school Tuesday, Oct. 23, in San Diego. Proposition 30 would boost the state sales tax by a quarter cent for four years and raise income taxes for seven years on those who make more than $250,000 annually.
Lenny Ignelzi/AP
EnlargeSupport for Gov. Jerry Brown?s plan to raise billions in taxes ? necessary to square California?s budget and avoid draconian budget cuts that would be triggered automatically ? has suddenly and seriously slipped to below 50 percent, two major state polls say.
Skip to next paragraph' +
google_ads[0].line2 + '
' +
google_ads[0].line3 + '
Subscribe Today to the Monitor
The question now becomes whether Governor Brown and his supporters can rescue the tax measure, known as Proposition 30, with less than two weeks left before Election Day.
On Thursday Brown brushed off news of the new poll results and expressed confidence that he would push the measure through, but history and conventional wisdom hold that tax measures rarely gain support in the waning days of a campaign.
Experts note also that the governor?s ability to win back support is hampered by the fact that a majority of the 40 percent of Californians who vote absentee have already cast their ballots.
Prop. 30 would temporarily raise taxes on individuals earning more than $250,000 annually and impose a quarter-cent hike in the state sales tax. If it fails, $6 billion in automatic spending cuts would be triggered starting Jan. 1, mostly from K-12 schools, but also from health and human services, including care for the disabled and seniors.
According to the new USC Dornsife/Los Angeles Times poll, support for Brown?s initiative has plunged nine percentage points in the past month to just 46 percent of registered voters.
A separate poll by the Public Policy Institute of California (PPIC) put support among likely voters at 48 percent, below the 50 percent needed for passage. That?s a four-point drop from their own poll a month ago.
Analysts say that more than just the state?s finances are imperiled if the ballot measure fails.
?The future of his governorship, indeed his legacy, rest on the passage of Prop. 30,? says David McCuan, professor of political science at Sonoma State University. ?If you need further evidence of this just look to how Arnold Schwarzenegger was emasculated with many trips to the ballot.?
Professor McCuan and others say the drop in support has come for two primary reasons. One is that Brown has failed to sufficiently convince voters to pass the measure, relying on the negative argument, that ?if it doesn?t pass, education will suffer? ? which many voters felt as a threat. The other reason is that a rival tax measure, Prop. 38, backed by deep pocket millionaires, began negative attack ads on Brown?s measure.
?Tax measures in California face two problems: The voters rarely approve tax increases, and intense moneyed opposition usually means voters are confused and thus will vote ?no,? ? says Robert Stern, former president of the Center for Governmental Studies.
Noting that only once in the last 10 years has a tax been passed ? a millionaire's tax for mental health funding ? he concludes, ?it is not unusual that Brown's initiative probably will lose.?
Jason Kidd All Star Game 2012 directv rashard lewis curacao curacao home run derby
If anyone is going to get their hands on new Nexus hardware first, it's going to be Google top-brass. So when photos from Senior Vice President of Engineering, Vic Gundotra, show up on his Google + with "Nexus 10" in the details, we pay attention. The pictures show some idyllic scenes from the beach, but what we're all interested in is the EXIF data. So, 2,046 by 1,536 you say? That's 3-megapixel by our calculations, which may not be the true original resolution of the image of course. With a big Google event just around the corner, though, we imagine we won't have to wait long to find out more.
Vic Gundotra posts Nexus 10 photos to Google + originally appeared on Engadget on Fri, 26 Oct 2012 08:47:00 EDT. Please see our terms for use of feeds.
PermalinkAndroid Central | Vic Gundotra (Google+) | Email this | Comments
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/S2uar2LUA-M/
the matrix oceans 11 ferris state hockey mary poppins john derbyshire kinkade thomas kinkade paintings
Weekends On The Web: Oct. 27-28, 2012
Central West End Halloween
Saturday, October 27, 2012 Venue: Central West End ?Time: 11:00am-Midnight
www.thecwe.org/events/cwe-halloween-2012/
Schedule
11am: Kids Costume Parade & Party
Noon: Trick or Treat Time
1pm: Canine Costume Parade
8pm?: Adult Costume Contest & Party
Apple Butter Festival
Date: Saturday & Sunday, October 27-28, 2012 Venue: Kimmswick, Missouri
Kimmswick Historical Society will be making and selling their famous Apple Butter at the Apple Butter Pavilion on Market Street. Booths fill the city park and line the streets of Kimmswick selling a variety of crafts and food items. Time: 10am-5pm each day http://www.visitkimmswick.com/
Fresh Hop Beer Festival
Date: Saturday, October 27, 2012 ?Venue: Schlafly Bottleworks ?Time: Noon-4pm
In celebration of the fall hop harvest, Schafly flys in fresh, wet hops from Washington State and shares them with the best breweries in town. Once the hoppy beers are brewed, Schalfly assembles them at this beer festival for sampling and savoring. http://www.schlafly.com/
Hey! There?s Nature in My Woods!
Date: Saturday, October 27, 2012 ?Venue: World Bird Sanctuary Time: 9am-11am
A family-friendly two-hour leisurely guided nature hike to see what kind of nature is in our woods. Learn about trees, rocks and who knows what else. Reservations required. http://www.worldbirdsanctuary.org/?
Mercy Children?s Hospital Boo at the Zoo Spooky Saturday
Date: Saturday, October 27, 2012 ?Venue: The Saint Louis Zoo in Forest Park
Mummies and daddies are invited to bring their little ghouls and goblins for safe and free trick-or-treating, entertainment, games and costume parade. Children are encouraged to wear costumes. Trick-or-treating from 9am-1pm ?www.stlzoo.org
Rural Heritage Day
Saturday, October 27, 2012 Venue: locations in and around Ste. Genevieve? Time: 9am-5pm
Come see how it used to be done, whether its farming, cooking, spinning, lace making, leather working, soap making, wood carving, gardening, or good old-fashioned games. Try the Lions Club?s vittles or bring a picnic. visitstegen.com/
D?j? Vu Spirit Reunion
Saturday, October 27, 2012 Venue: 1787 Memorial Cemetery at Fifth and Merchant Streets
Time: 5 pm-8 pm Cost: $5, Children ages 6-18 are $2.50, and children 5 and under are free.
Experience some of Ste. Genevieve?s notable and notorious spirits in Missouri?s oldest cemetery. Costumed spirits will present Ste. Genevieve?s past through stories. Proceeds benefit the Foundation for Restoration of Ste. Genevieve?s Memorial Cemetery Restoration project. www.historicstegen.org/
4th Annual Show Me State Disc Dog Championships
Date: Saturday & ?Sunday, October 27-28, 2012 Venue: Purina Farms
Watch human and canine teams compete in flying disc. Sat.: 10am-4pm Sun.: 9am-4pm? www.purinafarms.com
Classic Car Club Auto Show
Date: Sunday, October 28, 2012 ?Venue: Kemp Auto Museum Cost: FreeLargely manufactured between 1925 and 1948, the displaying vehicles are owned by private collectors of the Classic Car Club of America. Includes models from Cadillac, Duesenberg, Jaguar, Mercedes-Benz, Packard, Pierce Arrow, Rolls Royce and many more. Time:10am-3pm
www.kempautomuseum.com
St. Louis Symphony Live at Powell Hall Concert: The Wizard of Oz
Date: Saturday & ?Sunday, October 27-28, 2012 Venue: Powell Symphony Hall
Time: 7pm (Sat.); 2pm (Sun.)
Enjoy the 1939 classic on the big screen as the St. Louis Symphony orchestra performs the memorable soundtrack. www.stlsymphony.org
Les Miserables
Date: Saturday & ?Sunday, October 2728, 2012 Venue: The Fox Theatre
This brand new 25thanniversary production musical features glorious new staging and dazzlingly re-imagined scenery inspired by the paintings of Victor Hugo. Saturday at 2pm, 8pm ?Sunday at 2:00 p.m. http://www.fabulousfox.com/
Source: http://fox2now.com/2012/10/26/weekends-on-the-web-saturday-sunday/
holocaust remembrance day chesapeake energy dick clark death yom hashoah yolo liquidmetal gsa scandal
With a potentially monster storm approaching the U.S. East Coast just days ahead of Halloween, it's not surprising that weather forecasters have dubbed the intense Hurricane Sandy a "Frankenstorm." But there may be a better name for the incoming hurricane, NASA officials say.
Hurricane Sandy is currently a Category 1 storm on the Saffir-Simpson wind scale as it creeps northward in the Atlantic Ocean. The storm is expected to merge with another cold front early next week and could transform into a powerful hybrid tempest, according to the National Hurricane Center.
"Some forecasters are calling this combination of weather factors 'Frankenstorm' because of the close proximity to Halloween," officials with NASA's Goddard Space Flight Center in Greenbelt, Md., wrote in a storm update today (Oct. 26). "However, because Sandy is a woman's name, the storm could be considered a 'bride of Frankenstorm.'"
Sandy has grown in size such that its cloud cover blankets an area 2,000 miles (3,218 kilometers) across as the storm passed over the Bahamas, NASA officials said. [Photos: 'Frankenstorm' Hurricane Sandy from Space]
As of this afternoon, Hurricane Sandy was about 430 miles (695 kilometers) south-southeast of Charleston, S.C., and 30 miles (50 km) north-northeast of Great Abaco Island. The storm had maximum sustained winds of about 75 mph (120 kph) and was moving north at about 7 mph (11 kph).
Hurricanes and other major storms have names that progress in alphabetical order and alternate between the male and female genders. The storm before Sandy was called Rafael and the storm that immediately followed the "Frankenstorm" was named Tony.
The next major Atlantic storm to carry a female name will be called Valerie, according to the current cycle. Names beginning with the letters Q, U, X, Y and Z are left out of naming convention due to their limited number.
NASA and the National Oceanic and Atmospheric Administration (NOAA) are keeping constant watch on Hurricane Sandy using satellites that monitor the storm non-stop with radar and in visible light and infrared wavelengths. NASA's Tropical Rainfall Measuring Mission satellite has revealed spots of intense rainfall around the storm's center, Goddard officials explained.
"Storm surge is expected to be [a] big factor as Sandy approaches the Mid-Atlantic coast. Very rough surf and high and dangerous waves are expected to be coupled with the full moon," Goddard officials wrote. "The National Hurricane Center noted that the combination of a dangerous storm surge and the tide will cause normally dry areas near the coast to be flooded by rising waters."
NASA is providing constant updates, interviews and video to the public via its hurricane status website here. The term "Bride of Frankenstorm" was proposed by Goddard's Rob Gutro, Hal Pierce and Marshall Sheperd during today's updates.
You can follow SPACE.com Managing Editor Tariq Malik on Twitter?@tariqjmalik?and SPACE.com on Twitter?@Spacedotcom. We're also on?Facebook?&?Google+.
Copyright 2012 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.Source: http://news.yahoo.com/hurricane-sandy-actually-bride-frankenstorm-nasa-202053964.html
daytona 500 winner cleveland plain dealer barry sanders barry sanders john scott jimmie johnson juan pablo montoya crash
Harry Potter publisher Bloomsbury has reported revenue rises of 2% in the six months leading to the end of August this year, however overall the publisher?s pre-tax profits (stripping out costs for international relocation etc) fell by 40%, dropping to ?0.9m ($1.44 million) from ?1.5m on the previous year.
Digging a little deeper, however, ebook sales jumped 89% to ?4.5m from ?2.4m though it?s not clear exactly how the arrival of Harry Potter in digital format buoyed these figures.
JK Rowling first announced her intentions to take?Harry Potter into the digital realm last summer, with the launch of?Pottermore.com. The proposed October launch was put back to March this year with all seven novels rolling out. And although agreements were inked to take the novels to all the common ebook platforms, Pottermore was the main go-to for actually procuring the series. Amazon later secured an exclusive license to bring Harry Potter to Kindle Lending Libraries, despite not being able to sell the books directly.
However, while Bloomsbury does play a role in the ebook element of the Potter franchise, and receives a share of the revenues, it is for all intents and purposes a separate entity and won?t translate into the multi-billion pound money-spinner it enjoyed with the print books. Bloomsbury hasn?t provided separate sales figures for the Harry Potter series, but it does acknowledge the launch of Pottermore.com briefly in the report.
In terms of the broader picture, Bloomsbury reports a turnover of ?43.5m from March to August this year, up from ?42.4m on the same period in 2011, and despite the drop in profits, Chief executive Nigel Newton remained upbeat, noting the figures showed a ?positive trend? overall, as quoted in the Bookseller. ?The group continues to make good progress,? said. ?We have acquired two new businesses further boosting our presence in the academic market, particularly in the USA, and have launched our own sales and publishing operation in India, a market which has the potential to become one of the largest English language book markets in the world.?
Indeed, in July last year Bloomsbury acquired Continuum International Publishing Group, which represented almost ?7m of Bloomsbury?s print sales. But the six-month interim report points to other external factors for the drop in print sales:
?Bloomsbury?s print sales this period have also been affected by the Olympics, during which many people stayed away from the high street, and a market dominated by the best selling Fifty Shades of Grey and more specifically by a reduction in sales of Harry Potter titles year on year, following the release of the last film in that series in the summer of 2011.?
?Higher ebook sales and academic turnover continue to increase the weighting of our sales to the second half,? continued?Newton. ?In addition, we have a strong second-half list, including potential best sellers, and are targeting a significant number of rights and services contracts. We remain well positioned for the future and results continue to show a positive trend over the longer term.?
In terms of digital, which naturally comprised mainly of ebook sales, this now represents 10% of Group continuing turnover, compared to 6% in 2011, and 15% of the Adult division continuing turnover (2011: 9%). More adults read ebooks, it seems.
Image Credit ? Thinkstock
Source: http://thenextweb.com/media/2012/10/25/ebooks-drive-bloomsbury-turnover-but-profits-fall-overall/
neti pot iron chef bath and body works coupons jeff probst jeff probst king jong il dead south korea
A Microsoft store product advisor displays the new Surface table computer as customers enter the store as it opens Friday, Oct. 26, 2012 in Seattle. Friday was the first day of sales for the new Windows 8 operating system and the company's new tablet computer, the Surface. (AP Photo/Elaine Thompson)
A Microsoft store product advisor displays the new Surface table computer as customers enter the store as it opens Friday, Oct. 26, 2012 in Seattle. Friday was the first day of sales for the new Windows 8 operating system and the company's new tablet computer, the Surface. (AP Photo/Elaine Thompson)
Graphic shows global sales of personal computers, tablets and smartphones by operating system
Customers look at new Microsoft Surface tablet computers Friday, Oct. 26, 2012, at a Microsoft store in Seattle. Friday was the first day of sales for the new Windows 8 operating system and the company's new tablet computer, the Surface. (AP Photo/Elaine Thompson)
Caitlin Mullock, left, and Jessica Toman look over new Microsoft Surface tablet computers Friday, Oct. 26, 2012, at a Microsoft store in Seattle. Friday was the first day of sales for the new Windows 8 operating system and the company's new tablet computer, the Surface. (AP Photo/Elaine Thompson)
Customers look over new Microsoft Surface tablet computers Friday, Oct. 26, 2012, at a Microsoft store in Seattle. Friday was the first day of sales for the new Windows 8 operating system and the company's new tablet computer, the Surface. (AP Photo/Elaine Thompson)
NEW YORK (AP) ? With the launch of Windows 8, people are about to discover a computing experience unlike anything they've seen before. Here's a guide to getting past some of the hurdles.
The main thing to know is that Windows 8 is designed especially for touch-screen computers, to make desktops and laptops work more like tablets. It is Microsoft's way of addressing the popularity of tablets, namely the iPad. But Windows 8 will work with mouse and keyboard shortcuts, too. It'll take some getting used to, though.
There are two versions of Windows 8, or more precisely, there's Windows 8 and there's Windows RT. They look the same, but they run on different processing chips. Windows 8 runs on standard chips from Intel and AMD and is the version you'd get if you're upgrading your home desktop or notebook PC. Windows RT is the version for light, small tablets and laptop-tablet hybrids.
Windows 8 will run programs written for older versions of Windows. Windows RT won't. It's limited to applications specifically written for it and available through Microsoft's store. (As a consolation, a version of Microsoft Office is included free on Windows RT devices).
Here are some tips on how to navigate the new Windows:
? When you start a Windows 8 machine, you're greeted with a screen that shows the time and a pretty picture. To get past it with a touch-screen device, swipe upwards with your finger from the bottom edge of the screen. If you have a keyboard, hit any key.
? Next, you'll see a mosaic of Live Tiles, each representing an application. Programs specifically written for Windows 8 will run in this new environment, which is unofficially nicknamed Metro. Each application fills the screen when you run it. Applications written for older Windows versions will open up in something that looks very much like the old Windows Desktop environment. You can switch back and forth between Metro and the new Desktop, though Microsoft wants people to eventually use only Metro.
? The Desktop screen lacks a Start button, so it's hard to start programs from there. Microsoft's idea is that users should learn to go to the Metro tiles to start programs or access settings, even if many programs, including some Windows utilities, will open up in Desktop. To get back to the tiled Start screen with a mouse or touchpad, move the mouse cursor to the top right corner of the screen, then swipe it down to the "Start" icon that appears. If you have a touch screen, reveal the Start icon by swiping in from the right edge of the screen.
? In the Desktop environment, you can glance at the Taskbar to see which Desktop programs are running. If you're a mouse or touchpad user in Metro and want to see what's running, you have to know this trick: Move the cursor into the top left corner of the screen, then drag it down along the left edge of the screen. If you have a touch screen, swipe in from the left edge, then quickly swipe back in.
? Neither environment will show you programs that are running in the other environment, but if you have a touch screen, swiping in from the left side of the screen lets you jump between open applications. The "Alt-Tab" combination does the same thing with a keyboard, in case you aren't using a touch screen.
? There are two versions of Internet Explorer, one for each environment. A Web page you open in one doesn't appear in the other, so if you're trying to find your way back to a page, it helps to remember which browser you were using.
? When using Metro on a touch screen, you close a program by first swiping your finger down from the top edge of the screen. That shrinks the window. Then you swipe your finger down to the bottom edge of the screen. Don't stray to the right or left edges of the screen, or the app will end up "docked" in a column along that edge. You can perform the same action with a mouse cursor by clicking and dragging from the top edge of the screen, but using the old "Alt-F4" command is easier.
? In the Desktop version of Internet Explorer, you can see at a glance which pages you have open in "tabs." In Metro, each Web page fills the screen, leaving no room for tabs.
To see which other pages are open on a touch-screen computer, you swipe your finger down from the top of the screen to reveal thumbnails of the other windows. Don't sweep too far, or you'll shrink the window instead.
If you're using a mouse in Metro, you right-click anywhere on the screen to reveal the tabs. Of course, this means right-clicking no longer does any of things it can be used for in previous versions of Windows, such as letting you open a link in a new tab.
? When Microsoft introduced Windows 95, some people thought it was amusing and counterintuitive that the procedure for shutting down the computer began with the "Start" button. In Windows 8, that incongruity is gone along with the Start button, but shutting down with a mouse or touchpad isn't obvious either. Move the cursor into the top right corner of the screen. A menu will pop out. Sweep down to the "Settings" button that appears, and click it. Then click "Power," then "Shut down." If you're on a touch screen, start by swiping in from the right edge of the screen, then tap "Settings."
Associated Pressmars needs moms stephen curry hes just not that into you hes just not that into you texas longhorns texas longhorns francesca woodman
By Jericka Duncan
CLAYTON, N.J. (CBS) ? Eyewitness News spoke exclusively to a man coming out of the East Clayton Avenue home where two teens were charged with the murder of 12-year-old Autumn Pasquale.
When we asked the couple if they had anything to say, a man who didn?t identify himself said, ?I?m very sorry, other than that, we can?t talk about anything else.?
?People are angry and hurt and confused,? said Alyssa Gibson who lives near the murder suspects.?They don?t understand why another child would do this to a child,? she cried.
Gibson is one of several neighbors who?ve placed flowers, candles, and balloons near the growing memorial site for Autumn. This morning Autumn?s mother took a moment to visit and to grieve. As she left she held on tight to a teddy bear. Another sad reminder that a community is mourning the loss of a child.
?Makes me sick to my stomach just to even think, what these kids did, it?s just horrible,? said John Scafidi.
Authorities say the teens lured Pasquale into 308 E. Clayton Avenue on Saturday afternoon.
Police say she was strangled. Her body was dumped in a blue recycling container. Police located the container behind the house next door to the suspects?.
Throughout the day Wednesday, neighbors stopped and stared at the home where the attack allegedly happened. One woman wiped tears from her eyes and sat in silence, weeping for the little girl everyone hoped would return home alive.
Both juvenile suspects are being held at a detention center.
restaurant week type 2 diabetes occupy congress juan williams victor martinez alcatraz cruise ship
Data Monitoring Board Recommends that All Patients in Clinical Trial ?Cross Over? to Active Treatment with Pomalidomide
This Is Encouraging News for Pomalidomide Approval Now Expected Early 2013 US and Second Half of 2013 EU
NORTH HOLLYWOOD, Calif.--(BUSINESS WIRE)--Oct 24, 2012 - The International Myeloma Foundation (IMF) ? the oldest and largest foundation dedicated to improving the life and care of myeloma patients ? said pomalidomide, an investigational drug for multiple myeloma, has demonstrated overall survival even in patients who have undergone multiple previous treatments. The finding came during an ongoing international clinical trial of pomalidomide when the data safety monitoring board allowed all patients in the trial to receive pomalidomide instead of just a comparison regimen.
?The improvement in overall survival in the patients in the study taking pomalidomide is being described as ?statistically significant and clinically meaningful,' and we believe this will further support approval of this investigational drug,? said Brian G.M. Durie, M.D., Chairman and Co-Founder of the IMF. ?What is especially important to patients is that pomalidomide works even after resistance has developed to other IMiDs, proteasome inhibitors or even after stem cell transplant. Pomalidomide, alone or in powerful combinations with other drugs, will provide an important new option for patients who need new treatments.?
Pomalidomide is an experimental oral drug that attacks the cancer in multiple ways, fighting the cells directly, as well as stimulating the immune system. The US Food and Drug Administration has accepted pomalidomide for review with a decision expected no later than February 10, 2013. A decision by the EMA in Europe is anticipated later next year.
Susie Novis, President and Co-founder of the IMF noted, ?This is an important time for patients with multiple myeloma. The novel therapies VELCADE? and REVLIMID? changed the course of myeloma, providing extended remissions. The recent approval of KYPROLIS? provides a new option for patients who have exhausted all other treatments, and the anticipated approval of pomalidomide further opens the door to more treatment options for patients that hopefully will provide longer remissions and a better quality of life.?
Ms. Novis added, ?The IMF was instrumental in supporting approval of KYPROLIS with important patient and expert testimony. We will also work for pomalidomide approval with patient support and with research, and once it is approved, we have an active program to support insurance reimbursement for oral cancer drugs.?
Myeloma, also called multiple myeloma, is a cancer of cells in the bone marrow that affects production of red cells, white cells and stem cells and can damage bone. It is growing in numbers and affecting increasingly younger people. Although multiple myeloma was once ?a rare disease of the elderly,? it is affecting younger patients in greater numbers and even patients as young as those in their early twenties.
Pomalidomide is undergoing evaluation in an international phase III trial. According to the data safety monitoring board, the pomalidomide regimen met the study's primary endpoint of progression free survival as well as overall survival, a key secondary endpoint. Approval submissions have been based on pomalidomide with low-dose dexamethasone for patients with relapsed and refractory multiple myeloma.
ABOUT THE INTERNATIONAL MYELOMA FOUNDATION
Celebrating its 21st anniversary, the International Myeloma Foundation is the oldest and largest myeloma organization, reaching more than 215,000 members in 113 countries worldwide. A 501 (c) 3 non-profit organization dedicated to improving the quality of life of myeloma patients and their families, the IMF focuses on four key areas: research, education, support, and advocacy. To date, the IMF has conducted more than 250 educational seminars worldwide, maintains a world-renowned hotline, and established the International Myeloma Working Group (IMWG), a collaborative research initiative focused on improving myeloma treatment options for patients. The IMF can be reached at (800) 452-CURE (2873). The global website is www.myeloma.org.
?
Contact: Planet Communications
Deanne Eagle, 917-837-5866
?
?
Posted: October 2012
49ers vs giants giants vs 49ers san francisco 49ers san francisco 49ers sf 49ers joe paterno died 49ers game
